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Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Fatty acid synthase (FAS) has been found to be overexpressed in a wide range of epithelial tumors, including breast cancer. Pharmacologic inhibitors of FAS cause apoptosis of breast cancer cells and… Expand
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.
The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results in apoptosis of tumor cells. Therefore, FAS is considered to be… Expand
Molecular Features of the Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer
To characterize the molecular feature in prostate carcinogenesis and the putative transition from prostatic intraepithelial neoplasia (PIN) to invasive prostate cancer (PC), we analyzed… Expand
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
CD82, also known as KAI1, was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2 (ref. 1). The product of CD82 is KAI1, a 40- to 75-kDa tetraspanin… Expand
Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53
- Toshiki Mori, Yoshio Anazawa, Megumi Iiizumi, S. Fukuda, Yusuke Nakamura, H. Arakawa
- Biology, Medicine
- 25 April 2002
Interferon regulatory factors (IRFs) regulate transcription of interferon genes through DNA sequence-specific binding to these targets. Using a differential display method for examining gene… Expand
Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain
Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the 1 year survival rate among these patients remains less than 20%.… Expand
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer.
- Megumi Iiizumi, S. Bandyopadhyay, +12 authors K. Watabe
- Medicine, Biology
- Cancer research
- 15 September 2008
RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet to be clarified.… Expand
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis
Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway, has been shown to be overexpressed in various types of human cancer and is, therefore, considered to be an attractive… Expand
Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy.
- Megumi Iiizumi, W. Liu, S. K. Pai, E. Furuta, K. Watabe
- Biology, Medicine
- Biochimica et biophysica acta
- 1 December 2008
It is well recognized that the majority of cancer related deaths is caused by metastatic diseases. Therefore, there is an urgent need for the development of therapeutic intervention specifically… Expand
Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis
Prostate cancer is a major cause of cancer death and morbidity in western countries. However, because of its intrinsic nature of chemoresistance, there is only limited systemic therapy available for… Expand