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The overall goal of CSCL research is to design software tools and collaborative environments that facilitate social knowledge construction via a valuable assortment of methodologies, theoretical and operational Computer support for knowledge construction in collaborative learning environments. Computers in Human Behavior 21, 623–643], yet few studies(More)
The antiphospholipid antibodies (aPL) present in autoimmune disorders are associated with thromboembolic episodes, and their binding to phospholipids (PL) is mediated by a plasma cofactor, beta 2-glycoprotein I (beta 2GPI). Both PL and beta 2GPI seem necessary for binding, thus indicating that the two components comprise the epitope against which aPL are(More)
Autoimmune CL-rA need a plasma protein, beta 2GPI, to bind anionic PL. While beta 2GPI could be the true antigen, beta 2GPI binding to solid phase heparin did not determine its recognition by CL-rA when using patient plasmas. We tested plasmas from four patients with antiphospholipid syndrome in this study and no CL-rA binding to heparin sepharose was(More)
4 856 cases of primary lung carcinoma in the Rhônes-Alpes area have been collected from 1970 to 1980 by cytological examination. The validity of these data rests upon the fact that they come from the same laboratory. The percentage of small cell carcinomas has been calculated per year and per geographical area. An increasing incidence is observed starting(More)
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