Meghan B. Davis

Learn More
Pancreatic cancer is a leading cause of cancer-related death, largely due to metastatic dissemination. We investigated pancreatic cancer progression by utilizing a mathematical framework of metastasis formation together with comprehensive data of 228 patients, 101 of whom had autopsies. We found that pancreatic cancer growth is initially exponential. After(More)
Paracrine cross-talk between tumor cells and immune cells within the tumor microenvironment underlies local mechanisms of immune evasion. Signal transducer and activator of transcription 3 (STAT3), which is constitutively activated in diverse cancer types, is a key regulator of cytokine and chemokine expression in murine tumors, resulting in suppression of(More)
OBJECTIVES Small cell carcinoma (SCC) of the pancreas is a rare malignancy with a poor prognosis. We established and characterized a primary human pancreatic SCC cell line, designated A99. METHODS Cancer tissue was obtained from the liver metastasis of an SCC of the pancreas and xenografted into nude mice. The first-pass xenograft was then used to(More)
PURPOSE Because toll-like receptor (TLR) agonists have been well characterized as dendritic cell (DC) activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the antitumor response in vivo. EXPERIMENTAL DESIGN Granulocyte macrophage colony stimulating factor secreting whole cell tumor cell vector (GVAX) was(More)
Purpose: Because toll-like receptor (TLR) agonists have been well characterized as dendritic cell (DC) activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the antitumor response in vivo. Experimental Design: Granulocyte macrophage colony stimulating factor secreting whole cell tumor cell vector (GVAX) was(More)
Downlo crine cross-talk between tumor cells and immune cells within the tumor microenvironment underlies echanisms of immune evasion. Signal transducer and activator of transcription 3 (STAT3), which is tutively activated in diverse cancer types, is a key regulator of cytokine and chemokine expression in e tumors, resulting in suppression of both innate and(More)
  • 1