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The retinal pigment epithelium (RPE) is indispensable for vertebrate eye development and vision. In the classical model of optic vesicle patterning, the surface ectoderm produces fibroblast growth factors (FGFs) that specify the neural retina (NR) distally, whereas TGFβ family members released from the proximal mesenchyme are involved in RPE specification.(More)
Carma-1 is required for B cell receptor-/CD40-and T cell receptor-/CD28-induced Band T-cell activation via JNK and NF-βB. In B cells, Carma-1 becomes phosphorylated by PKCβ, leading to its oligomerization. Subsequent Bcl10 binding induces IKKβ-activation and, thereby, canonical NF-κB signalling. Despite these findings it is still unknown how exactly Carma-1(More)
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