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Adult myelination: wrapping up neuronal plasticity
TLDR
This review examines how myelin plasticity can operate alongside neurogenesis and synaptic plasticity to influence information processing and transfer in the mature CNS. Expand
Low‐intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain
TLDR
It is determined that low intensity rTMS (LI‐rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theTA burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. Expand
Evaluating Tissue-Specific Recombination in a Pdgfrα-CreERT2 Transgenic Mouse Line
TLDR
The data suggest that Pdgfrα-CreERT2 transgenic mice can be used to achieve robust recombination in OPCs, while having a minimal effect on most PDGFRα+ cell populations outside of the CNS. Expand
Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function
TLDR
It is shown that OPCs are ciliated in vitro and in vivo, and that they disassemble their primary cilia as they progress through the cell cycle. Expand
Conditionally and acutely ablating Kif3a from oligodendrocyte progenitor cells impairs primary cilum assembly and cell function
TLDR
It is shown that OPCs are ciliated, both in vitro and in vivo, while mature oligodendrocytes are not and that preventing cilium assembly reduces both OPC proliferation and oligodendedrogenesis. Expand