Megan M. Kaneda
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PI3Kγ is a molecular switch that controls immune suppression
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T… Expand
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.
UNLABELLED Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a low 5-year survival rate, yet new immunotherapeutic modalities may offer hope for this and other intractable… Expand
Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.
- Andrew J. Gunderson, Megan M. Kaneda, +15 authors L. Coussens
- Medicine, Biology
- Cancer discovery
- 1 March 2016
UNLABELLED Pancreas ductal adenocarcinoma (PDAC) has one of the worst 5-year survival rates of all solid tumors, and thus new treatment strategies are urgently needed. Here, we report that targeting… Expand
RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee
- Hongmei Li-Byarlay, Yingying Li, +10 authors G. Robinson
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 July 2013
Studies of DNA methylation from fungi, plants, and animals indicate that gene body methylation is ancient and highly conserved in eukaryotic genomes, but its role has not been clearly defined. It has… Expand
Integrin CD11b activation drives anti-tumor innate immunity
Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing and tumor progression. Recruitment of these cells is regulated by… Expand
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.
Checkpoint inhibitors have demonstrated efficacy in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). However, the majority of patients do not benefit from these… Expand
PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression
Myeloid-derived suppressor cells and tumor-associated macrophages, aided by PI3Kγ and integrin α4, accumulate in tumors and block antitumor immune responses. Suppression of PI3Kγ or integrin α4… Expand
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression
This corrects the article DOI: 10.1038/nature19834
Abstract 3650: PI3-kinase gamma controls the macrophage M1-M2 switch, thereby promoting tumor immunosuppression and progression
Innate immune cells (macrophages, monocytes and neutrophils) rapidly migrate to sites of tissue damage where they initially activate T cells (M1 classical response). These cells gradually transition… Expand
Lab OHSU Center for Spatial Systems Biomedicine Platelet-Derived Soluble and Membrane-Bound Proteins Differentially Influence C-MYC Expression in Pancreatic Cancer Cells
Despite the development of promising targeted cancer therapeutics, many treatments have limited efficacy in patients over time. Often this is due to the ability of aberrant signaling pathways to… Expand