• Publications
  • Influence
Ebf2 is a selective marker of brown and beige adipogenic precursor cells
Significance High levels of brown/beige fat activity protects animals against metabolic disease, but there has been little known about the precursor cells that mediate the expansion of brown or beigeExpand
  • 132
  • 11
  • PDF
SnapShot: Brown and Beige Adipose Thermogenesis
Brown and beige adipose tissues have been identified as potential therapeutic targets for combating diet-induced obesity and metabolic disease. Here, we present transcriptional and developmentalExpand
  • 25
  • 4
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
Rapamycin extends life span in mice, yet paradoxically causes lipid dysregulation and glucose intolerance through mechanisms that remain incompletely understood. Whole-body energy balance can beExpand
  • 48
  • 3
PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
Brown adipose has the potential to counteract obesity, and thus, identifying signaling pathways that regulate the activity of this tissue is of great clinical interest. PRDM16 is a transcriptionExpand
  • 24
  • 1
Targeting PPAR&ggr; in the epigenome rescues genetic metabolic defects in mice
Obesity causes insulin resistance, and PPAR&ggr; ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat dietExpand
  • 26
  • 1
  • PDF
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.
Metabolic pathways dynamically regulate tissue development and maintenance. However, the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their local niche are poorlyExpand
  • 8