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Children exposed to alcohol prenatally suffer from a variety of behavioral alterations, including hyperactivity and learning deficits. Given that women continue to drink alcohol during pregnancy, it is critical that effective interventions and treatments be identified. Previously, we reported that early postnatal choline supplementation can reduce the(More)
Humoral hypercalcemia of malignancy (HHM) is a paraneoplastic syndrome rarely associated with pancreatic adenocarcinoma. Parathyroid hormone-related peptide (PTHrP) is the central mediator of this condition. In our patient, hypercalcemia associated with elevated PTHrP was the initial manifestation of metastatic pancreatic adenocarcinoma. Successful(More)
For patients who have primary cutaneous melanoma, tumor thickness is the most significant prognostic factor. In addition, other factors, including Clark's level (In thin melanoma), anatomic site of tumor, tumor histology (especially ulceration), patient age, and gender all have prognostic significance. With regional lymph node metastases, the number of(More)
3073 Background: SYN-D is a pentapeptide with a unique mechanism of action that potentially differs from microtubule stabilizers (taxanes and epothilones) and tubulin inhibitors (vinca alkaloids and other dolastatins) as it is postulated to inhibit microtubule nucleation. SYN-D possesses broad, potent antitumor activity, and favorable pharmacological and(More)
RATIONALE AND OBJECTIVES The authors assess performing hepatic magnetic resonance imaging (MRI) after arterial portography with manganese dipyridoxal diphosphate (MnD-PDP), a hepatobiliary contrast agent, as an invasive but potentially highly sensitive means of focal lesion detection. METHODS Eight pigs underwent superior mesenteric artery catheterization(More)
A newly designed flow support catheter with a supporting wire mesh cage which can be expanded into a tubular configuration and then readily reduced was evaluated in mongrel dogs. Regional myocardial blood flow (RMBF) was measured using the radioactive microsphere technique in the area of both balloon-denuded instrumented and control non-instrumented(More)
RATIONALE AND OBJECTIVES The authors attempted to determine the importance of benign but nonspecific findings from an adequate sample obtained with image-guided, fine-needle aspiration biopsy (FNAB) of the breast. MATERIALS AND METHODS Four hundred thirty-seven image-guided FNAB specimens obtained over a 4-year period were reviewed. Pathologic results,(More)
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