Megan G Holcomb

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OBJECTIVE Much controversy exists and many questions remain unanswered about the effects of hormone therapy (HT) on cognition in postmenopausal women. There is growing evidence suggesting that HT compounds containing conjugated equine estrogen (CEE) have negative effects on cognition whereas 17β-estradiol (17β-E) either has positive or neutral effects. The(More)
BACKGROUND AND PURPOSE Rabbit aneurysm models are used for the testing of embolization devices and elucidating the mechanisms of human intracranial aneurysm growth and healing. We used RNA-sequencing technology to identify genes relevant to induced rabbit aneurysm biology and to identify genes and pathways of potential clinical interest. This process(More)
BACKGROUND To determine the effects of memantine on cognition in a normal population of postmenopausal women with putative risk factors for Alzheimer's disease (AD) using a built-in control for the genetic risk factor for AD (apoE-epsilon4 status). METHODS A prospective, open-label, 6-month pilot medication trial with memantine and follow-up after(More)
A clinical sample of 20 sexual harassment victims who were successful in obtaining damage awards for trauma through the judicial system were sources of this descriptive study. Ratings of physical coercion of the harassment, MMPI-2 scores, and ratings on DSM-IV symptoms were analyzed. The majority of subjects met the DSM-IV criteria of Post-Traumatic Stress(More)
OBJECTIVE This study investigated the psychometric properties of the Frontal Systems Behavior Scale (FrSBe) in an acute traumatic brain injury (TBI) population across indices of factor structure, reliability, and validity. METHOD Data were collected from 101 individuals undergoing acute rehabilitation for moderate and severe TBI both upon emergence from(More)
BACKGROUND Recent literature on traumatic brain injury (TBI), though mixed when reporting outcomes, seems collectively to suggest possible gender advantage for women in postinjury recovery, especially in executive functions. Hormonal neuroprotection, through female reproductive hormones, is often proposed as an underlying factor in these results. We(More)
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