Megan Fitzpatrick

Michele K. Evans2
Nicole Noren Hooten2
2Michele K. Evans
2Nicole Noren Hooten
1David McCown
1Bernd Eisele
1Alan B. Zonderman
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MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs. Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease. Although we and others have found an age-dependent decrease in miRNA expression in peripheral blood(More)
L4 and L22, proteins of the large ribosomal subunit, contain globular surface domains and elongated 'tentacles' that reach into the core of the large subunit to form part of the lining of the peptide exit tunnel. Mutations in the tentacles of L4 and L22 confer macrolide resistance in a variety of pathogenic and non-pathogenic bacteria. In Escherichia coli,(More)
  • Nicole Noren Hooten, Megan Fitzpatrick, Kari Kompaniez, Kimberly D. Jacob, Brittany R. Moore, Julia Nagle +3 others
  • 2012
Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEscherichia coli endonuclease VIII, have(More)
BACKGROUND Perivascular epithelioid cell tumors (PEComas) are a rare group of neoplasms composed of epithelioid cells that express both melanocytic and myoid markers. When considering PEComas of the female genital tract, the uterus is the most common location. Involvement of the ovary in the context of a primary uterine PEComa, in the absence of systemic(More)
The failure of current Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more efficacious and safer replacement vaccines. With the availability of genetic techniques for constructing(More)
The Whooping Crane is an endangered species native to North America and there are approximately 575 in existence. There have been recent efforts to provide ecologists with a tool to study the multifaceted behavior of the endangered species. Like many species, cranes display distinctly identifiable movements while being threatened, acting territorial,(More)
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