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Although one proposed function of both the striatum and its major dopamine inputs is related to coding rewards and reward-related stimuli, an alternative view suggests a more general role of the striatum in processing salient events, regardless of their reward value. Here we define saliency as an event that both is unexpected and elicits an(More)
Implicit motor learning tasks typically involve comparisons of subject responses during a sequence versus a random condition. In neuroimaging, brain regions that are correlated with a sequence are described, but the temporal relationship of sequence versus nonsequence conditions is often not explored. We present a functional magnetic resonance imaging(More)
OBJECTIVE The authors' goal was to determine whether patients with bipolar II disorder had altered regional brain responses to novel motor sequences. METHOD Regional cerebral blood flow was measured with positron emission tomography in 13 patients with bipolar II disorder and 14 healthy comparison subjects. Participants performed a serial reaction time(More)
Using functional magnetic resonance imaging (fMRI), we studied the neural correlates of the complexity of rhythmic finger tapping. Our experiments measured the brain activity of 13 subjects performing rhythmic tapping on a response box with multistable rhythms of 1 to 5 different interresponse intervals. From the button press response times, we constructed(More)
Auditory nerve and brain stem evoked responses were summated from multiple scalp and earlobe electrodes from five subjects with normal hearing to determine the spatial voltage relationships along the coronal and/or sagital planes that make up the electrode array. All recordings maintained their positive polarity, and polarity inversions were not observed at(More)
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