Megan E Calos

Learn More
Parkinson's disease (PD) is a neurodegenerative disease characterized by akinesia, bradykinesia, resting tremors and postural instability. Although various models have been developed to explain basal ganglia (BG) pathophysiology in PD, the recent reports that dominant beta (β) oscillations (12-30Hz) in BG nuclei of PD patients and parkinsonian animals(More)
Deep brain stimulation (DBS) employing high-frequency stimulation (HFS) is commonly used in the globus pallidus interna (GPi) and the subthalamic nucleus (STN) for treating motor symptoms of patients with Parkinson's disease (PD). Although DBS improves motor function in most PD patients, disease progression and stimulation-induced nonmotor complications(More)
Seizures occur in the basal ganglia (BG) of epileptic patients and in animal models of epilepsy, but there is relatively little known about how these events are gated and/or propagated through this structure. Here, we present and characterize a model of in vitro seizure-like events (SLEs) in the striatum by applying chemostimulants to brain slices from(More)
The mechanism of high-frequency stimulation used in deep brain stimulation (DBS) for Parkinson's disease (PD) has not been completely elucidated. Previously, high-frequency stimulation of the rat entopeduncular nucleus, a basal ganglia output nucleus, elicited an increase in [K(+)](e) to 18 mm, in vitro. In this study, we assessed whether elevated K(+) can(More)
PURPOSE We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: perfusion of low (0.25 mm) Mg(2+) and(More)
28 Deep brain stimulation (DBS) employing high frequency stimulation (HFS) is commonly used in the globus 29 pallidus interna (GPi) and the subthalamic nucleus (STN) for treating motor symptoms of patients with 30 Parkinson's disease (PD). While DBS improves motor function in most PD patients, disease progression and 31 stimulation-induced non-motor(More)
Previously, we found that rat hippocampal CA3 interneurons become hyperactive with increasing concentrations of extracellular K(+) up to 10 mM. However, it is unclear how this enhanced interneuronal activity affects pyramidal neurons. Here we voltage-clamped rat hippocampal CA3 pyramidal neurons in vitro at 0 mV to isolate γ-aminobutyric acid(More)
12 13 Running title: cyclic inhibitory postsynaptic currents in pyramidal neurons 14 15 16 17 Number of figures: 7 18 Number of pages: 35 19 Number of tables: 0 20 21 Mailing and reprint request information: 22 23 Dr. Damian Shin 24 Albany Medical College 25 Abstract 37 Previously, we found that rat hippocampal CA3 interneurons become hyper-active with 38(More)
  • 1