Megan Connick

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A high-performance liquid chromatography (HPLC) method has been developed to quantify the major and modified nucleoside composition of total, unfractionated transfer RNA. The method is rapid and sensitive and offers a high degree of chromatographic resolution suitable for quantifying both stable and unstable modified nucleosides. It is nondestructive and(More)
Interferon (IFN)-gamma and macrophages (Mphi) play key roles in acute, persistent, and latent murine cytomegalovirus (MCMV) infection. IFN-gamma mechanisms were compared in embryonic fibroblasts (MEFs) and bone marrow Mphi (BMMphi). IFN-gamma inhibited MCMV replication in a signal transducer and activator of transcription (STAT)-1alpha-dependent manner much(More)
4. Schumann GL. Plant diseases: their biology and social impact. St. Paul: American Phytopathological Society Press; 1993. 5. Goodwin SB, Smart CD, Sandrock RW, Deahl KL, Punja ZK, Fry WE. Genetic change within populations of Phytopthora infestans in the United States and Canada during 1994 to 1996—role of migration and recombination. Phytopathology(More)
Interferon (IFN)g and macrophages (M w ) play key roles in acute, persistent, and latent murine cytomegalovirus (MCMV) infection. IFNg mechanisms were compared in embryonic fibroblasts (MEFs) and bone marrow M w (BMM w ). IFNg inhibited MCMV replication in a signal transducer and activator of transcription (STAT)-1 a –dependent manner much more effectively(More)
CD4 T cells and interferon gamma (IFN-gamma) are required for clearance of murine cytomegalovirus (MCMV) infection from the salivary gland in a process taking weeks to months. To explain the inefficiency of salivary gland clearance we hypothesized that MCMV interferes with IFN-gamma induced antigen presentation to CD4 T cells. MCMV infection inhibited(More)
CD4 T cells and interferon g (IFNg ) are required for clearance of murine cytomegalovirus (MCMV) infection from the salivary gland in a process taking weeks to months. To explain the inefficiency of salivary gland clearance we hypothesized that MCMV interferes with IFNg induced antigen presentation to CD4 T cells. MCMV infection inhibited IFNg –induced(More)
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