Megan Bingley

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Mutations in spastin are the most common cause of hereditary spastic paraplegia (HSP) but the mechanisms by which mutant spastin induces disease are not clear. Spastin functions to regulate microtubule organisation, and because of the essential role of microtubules in axonal transport, this has led to the suggestion that defects in axonal transport may(More)
The commonest cause of hereditary spastic paraplegia (HSP) is mutation in the spastin gene. Both the normal function of spastin in the central nervous system and the mechanism by which mutation in spastin causes axonal degeneration are unknown. One hypothesis is that mutant spastin disrupts microtubule dynamics, causing an impairment of organelle transport(More)
Hereditary spastic paraplegia (HSP) is a collection of neurological disorders characterized by developmental failure or degeneration of motor axons in the corticospinal tract and progressive lower limb spasticity. SPG4 mutations are the most common cause of autosomal dominant HSP and Spastin (the SPG4 gene product) is a microtubule severing protein that(More)
SALINE-FILLED g lass microelectrodes generate potentials in solutions of low ionic strength such as those in which fresh water amoebae are cultured (BINGLEV, 1963; BINGLEY, 1964; BATUEVA, 1964; ANDERSON, 1964; KAMIYA, 1964). These, together with values for electrode resistance, are sensitive to external cation concentration change. The passage of a(More)
  • Megan Bingley
  • Physiological chemistry and physics and medical…
  • 1994
Nitella flexilis living in Surrey ponds shows an unusual response to external electrical stimulation. This response is shorter (250 milliseconds) than the normal response (5 seconds), nor does it seem to obey the all-or-none law; decreasing the level of stimulus introduces a delay in its appearance. Microelectrode studies suggest that this response though(More)
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