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The protective effects of the selective adenosine A1 receptor agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA), the selective adenosine A2A receptor agonist, 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA), and the non-selective agonist, 5'-N-ethylcarboxamidoadenosine (NECA) were studied against lethal seizures induced by intraperitoneal (i.p.)(More)
The adenosine A2A receptor subtype is one of the four adenosine receptors that have been identified in the mammalian organism. In addition to being found in blood vessels, platelets and polymorphonuclear leukocytes, the A2A receptors are abundant in the central nervous system, especially in the striatum. The recent development of selective A2A receptor(More)
Interleukin 10 is an antiinflammatory cytokine and inhibits the production of tumor necrosis factor. We have previously found that intracerebroventricular (i.c.v.) administration of recombinant human interleukin 10 inhibits brain tumor necrosis factor production induced by an i.c.v. injection of lipopolysaccharide in mice. In view of its possible(More)
Focal cerebral ischemia in rats produces elevated levels of tumor necrosis factor (TNF)alpha in the ischemic brain region. To better understand the modulation of TNF during brain ischemia processes we carried out studies in a model of permanent middle cerebral artery occlusion (MCAo) in the rat. In non-treated ischemic animals, the maximum expression of TNF(More)
The Mongolian gerbil is recognized as a suitable experimental model for studying epileptiform seizures. About 10–20% of the gerbils provided by animal breeders show convulsions when placed in a new laboratory environment or handled for drug administration. In this review, the usefulness of the gerbil is critically evaluated on the basis of the literature(More)
A method for construction of a neopenis in female-to-male transsexual patients is described. The method consisted of inferior transposition of a rectus abdominis island muscle flap with resurfacing using a radial forearm free flap. Excellent internal support and a natural looking appearance was achieved. This technique was considered to be better than any(More)
The effects of the dopamine D1 receptor full agonist, A68930, on sleep-wake patterns and grooming behaviour were studied in the rat. The partial dopamine D1 receptor agonist, SKF 38393, was used for comparison. A68930 (0.003-0.3 mg/kg s.c.) increased waking time, reduced the amount of rapid eye movement (REM) sleep and enhanced spontaneous grooming dose(More)
The early effects of 5 or 10 min global cerebral ischemia, sham operation and halothane anesthesia were evaluated in Mongolian gerbils by means of electroencephalography (EEG), neurological examination and passive avoidance training. The “ischemia-sensitive” gerbils (33% and 64% of the 5 and 10 min ischemic groups, respectively) died during carotid ligation(More)
BACKGROUND The aim of this study was to test the ex-vivo biomechanical properties of acutely expanded scalp flaps, in order to quantitatively assess the efficacy of acute scalp expansion. METHODS A total of 14 fresh male cadavers were used for the study. In each cadaver, a rectangular (4 x 10 cm), laterally-based flap was designed on each side of the(More)
Monitoring heart rate (HR) and ventilatory rate (VR) during defined sensory stimuli and during aggressive and submissive social interactions has provided additional information of a crayfish’s physiological state which is not achieved by behavioral observations. In this study, the HR and VR of crayfish were monitored before, during and after the act of(More)