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Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normalExpand
Combinatorial Control of Smooth Muscle–Specific Gene Expression
Evidence is presented in support of the notion that SMC-specific gene regulation is not controlled by a fewSMC- specific transcription factors but rather by complex combinatorial interactions between multiple general and tissue-specific proteins. Expand
Smooth Muscle &agr;-Actin Gene Requires Two E-Boxes for Proper Expression In Vivo and Is a Target of Class I Basic Helix-Loop-Helix Proteins
Results provide the first evidence of E-box–dependent regulation of a SMC differentiation marker gene in vivo in transgenic mice and suggest that class I bHLH factors and their inhibitors, Id and Twist, may play an important role in control ofSMC differentiation and phenotypic modulation. Expand
PIAS1 Activates the Expression of Smooth Muscle Cell Differentiation Marker Genes by Interacting with Serum Response Factor and Class I Basic Helix-Loop-Helix Proteins
Results provide novel evidence that PIAS1 modulates transcriptional activation of SMC marker genes through cooperative interactions with both SRF and class I bHLH proteins. Expand