Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway
- Mee-Sup Yoon, Guangwei Du, J. Backer, M. Frohman, J. Chen
- Biology, Medicine
- The Journal of cell biology
- 31 October 2011
In response to amino acid availability, the class III PI-3-kinase hVps34 activates the phospholipase PLD and mTORC1 signaling to regulate mammalian cell size.
The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
- Mee-Sup Yoon
- Biology, Medicine
- Nutrients
- 1 July 2016
Insulin is required for maintenance of glucose homeostasis. Despite the importance of insulin sensitivity to metabolic health, the mechanisms that induce insulin resistance remain unclear.… Expand
Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect*
- Mee-Sup Yoon, Y. Sun, Edwin J Arauz, Y. Jiang, J. Chen
- Biology, Medicine
- The Journal of Biological Chemistry
- 7 July 2011
Phosphatidic acid (PA) is a critical mediator of mitogenic activation of mammalian target of rapamycin complex 1 (mTORC1) signaling, a master regulator of mammalian cell growth and proliferation. The… Expand
Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation*
- J. Kim, Mee-Sup Yoon, J. Chen
- Biology, Medicine
- The Journal of Biological Chemistry
- 29 October 2009
Nutrient overload is associated with the development of obesity, insulin resistance, and type II diabetes. High plasma concentrations of amino acids have been found to correlate with insulin… Expand
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
- Mee-Sup Yoon
- Chemistry, Medicine
- Nutrients
- 27 October 2017
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two… Expand
Distinct amino acid–sensing mTOR pathways regulate skeletal myogenesis
- Mee-Sup Yoon, J. Chen
- Biology, Medicine
- Molecular biology of the cell
- 1 December 2013
Amino acid–sensing mTOR signaling controls the homeostasis of skeletal myogenesis. The Rag GTPases negatively regulate differentiation by activating mTORC1 and subsequently suppressing the… Expand
mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
- Mee-Sup Yoon
- Biology, Medicine
- Front. Physiol.
- 17 October 2017
Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase,… Expand
PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
- Mee-Sup Yoon, J. Chen
- Biology, Medicine
- Journal of Cell Science
- 1 February 2008
A mammalian target of rapamycin (mTOR) pathway is essential for the differentiation of cultured skeletal myoblasts in response to growth factor withdrawal. Previously, phospholipase D (PLD) has been… Expand
XPLN is an endogenous inhibitor of mTORC2
- Nidhi Khanna, Y. Fang, Mee-Sup Yoon, J. Chen
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 16 September 2013
Significance Mammalian target of rapamycin complex 2 (mTORC2) controls a wide range of cellular and developmental processes and is a potential target for therapeutic strategies against a range of… Expand
Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)*
- Yejing Ge, Mee-Sup Yoon, J. Chen
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 August 2011
The mammalian target of rapamycin (mTOR) is essential for skeletal myogenesis through controlling distinct cellular pathways. The importance of the canonical mTOR complex 1 signaling components,… Expand