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Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway
In response to amino acid availability, the class III PI-3-kinase hVps34 activates the phospholipase PLD and mTORC1 signaling to regulate mammalian cell size.
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The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
Insulin is required for maintenance of glucose homeostasis. Despite the importance of insulin sensitivity to metabolic health, the mechanisms that induce insulin resistance remain unclear.Expand
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Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect*
Phosphatidic acid (PA) is a critical mediator of mitogenic activation of mammalian target of rapamycin complex 1 (mTORC1) signaling, a master regulator of mammalian cell growth and proliferation. TheExpand
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Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation*
Nutrient overload is associated with the development of obesity, insulin resistance, and type II diabetes. High plasma concentrations of amino acids have been found to correlate with insulinExpand
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The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms twoExpand
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Distinct amino acid–sensing mTOR pathways regulate skeletal myogenesis
Amino acid–sensing mTOR signaling controls the homeostasis of skeletal myogenesis. The Rag GTPases negatively regulate differentiation by activating mTORC1 and subsequently suppressing theExpand
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mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase,Expand
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PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
A mammalian target of rapamycin (mTOR) pathway is essential for the differentiation of cultured skeletal myoblasts in response to growth factor withdrawal. Previously, phospholipase D (PLD) has beenExpand
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XPLN is an endogenous inhibitor of mTORC2
Significance Mammalian target of rapamycin complex 2 (mTORC2) controls a wide range of cellular and developmental processes and is a potential target for therapeutic strategies against a range ofExpand
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Raptor and Rheb Negatively Regulate Skeletal Myogenesis through Suppression of Insulin Receptor Substrate 1 (IRS1)*
The mammalian target of rapamycin (mTOR) is essential for skeletal myogenesis through controlling distinct cellular pathways. The importance of the canonical mTOR complex 1 signaling components,Expand
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