Mediha Sahin

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Approximately 40-50% of individuals affected by tuberous sclerosis (TSC) develop autism spectrum disorders (ASDs). One possible explanation for this partial penetrance is an interaction between TSC gene mutations and other risk factors such as gestational immune activation. In this study, we report the interactive effects of these two ASD risk factors in a(More)
Distal partial trisomies involving the region 1q32 have been associated with dysmorphic features and developmental delay [1-11]. To further define the critical region for developmental delay and to investigate the genotype-phenotype association of 1q trisomy syndrome, we report two patients with much smaller (3 Mb and 3.5 Mb in size) trisomic regions on(More)
Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and present evidence of cerebellar deficits in cGMP(More)
The literature on ethnic entrepreneurship has identified a blend of structural and cultural factors that influence the step towards ethnic entrepreneurship. An important issue is whether ethnic entrepreneurs produce for their own ethnic niches or whether they try to cover a wider market of customers. This difference between so-called internal and external(More)
This paper studies the driving forces for successful migrant entrepreneurship in Amsterdam. Three categories of migrants are investigated, viz. Moroccans, Surinamese, and Turks. Particular attention is paid to their personal and business characteristics. An extensive field survey was undertaken to identify the main background factors which influence the(More)
Nowadays, migrants form a significant share of the urban population, and their business is critical for urban economic growth. This paper addresses the key factors determining the position of migrant entrepreneurs in the urban economy in the Netherlands. In order to develop a solid assessment of CSFs for migrant entrepreneurs, and to understand business(More)
In this paper we develop and test a conceptual model of the key relationships concerning the business performance and success of ethnic entrepreneurs. To that end, an explanatory modei'GALAXY' is presented which serves as a framework for mapping out the impact that various background factors are assumed to have on the economic performance of ethnic(More)
This study focuses on the external orientations of the second-generation migrant entrepreneurs by addressing in particular the way – and the extent to which – the choice for entrepreneurship is made by higher-educated young ethnic generations. The empirical data of our study is based on in-depth personal interviews. We employed a recently developed(More)
Both locally and globally, we are witnessing a rising interest in innovative entrepreneurial activity as an engine for economic growth. The economic performance of firms (or organizations) can be measured by, inter alia, innovation indicators, market shares, birth/death rates, investment rates and the like, while there is also a(More)