Meaghann Shaw Weaver

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The effect of acute and chronic administration of the 5-HT1A agonist buspirone on successive negative contrast was investigated in Experiments 1-6. Contrast in consummatory behavior was induced by shifting rats from a 32% to a 4% sucrose solution. Experiments 1-5 showed that buspirone (0.125, 0.25, 0.5, 1.0, 2.0, 15.0 mg/kg) was ineffective in alleviating(More)
Three experiments investigated the role of temporal grouping on auditory stream segregation. For sounds that formed frequency streams (e.g., 400 Hz, 500 Hz, 1600 Hz, and 2000 Hz), the effect of rhythm was minimal. Temporal grouping did not affect judgments of stream segregation and did not affect difficulty of sequence identification. In contrast, for(More)
This study compared N-methyl-D-aspartate (NMDA)-stimulated increases in intracellular calcium in fura-2-loaded neurons dissociated from newborn rat brainstem (EC50 in microM; 6.4), cerebellum (9.5), forebrain (6.3), and hippocampus (10.6). Ethanol inhibition of the response to 25 microM NMDA differed among the regions. The NMDA response in hippocampus was(More)
riers in the 6T wire. [3] Holes are trapped by defects in the crystal, which reduces the number of mobile carriers and hinders the movement of untrapped positive-charge carriers. Charge trapping can be reversed, however, by applying a positive-gate voltage (backbiasing) to force trapped holes out of trap states via electrostatic repulsion. As seen from the(More)
BACKGROUND Potential exposure to carbon monoxide (CO) in private homes is largely unquantified. AIM To estimate prevalence of potential exposure to CO in residential dwellings and describe associated interventions in an inner-city community. METHODS A housing association in London, Hackney Homes, began fitting CO alarms in the 22,831 local authority(More)
The present studies investigated the effects of glutathione (GSH; gamma-glutamylcysteinylglycine) and its oxidized form (GSSG) on neuronal N-methyl-D-aspartate (NMDA) receptor activation in both acute and chronic preparations of ethanol exposure. It was demonstrated using fura-2-loaded dissociated brain cells from newborn rat pups that both GSH and GSSG(More)
Medical providers are trained to investigate, diagnose, and treat cancer. Their primary goal is to maximize the chances of curing the patient, with less training provided on palliative care concepts and the unique developmental needs inherent in this population. Early, systematic integration of palliative care into standard oncology practice represents a(More)
BACKGROUND Given the burden of childhood cancer and palliative care need in Africa, this paper investigated the paediatric and palliative care elements in cancer control plans. METHODS We conducted a comparative content analysis of accessible national cancer control plans in Africa, using a health systems perspective attentive to context, development,(More)
BACKGROUND Retinoblastoma, the most common intraocular tumor globally, represents a curable cancer when diagnosed early and treated promptly. Delay to diagnosis, lag time prior to treatment initiation, and abandonment of treatment including upfront treatment refusal, represent stark causes of high retinoblastoma mortality rates in low- and middle- income(More)
An experiment manipulating both reward-magnitude contrast and delay of reinforcement is reported. The results indicated that odor cues are produced under conditions of delayed large-reward versus nonreward contrast but not under large- versus small-reward contrast. Additional magnitude and delay manipulations that resulted in the elimination of odor-based(More)