Meagan Sullivan

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BACKGROUND Irregular bleeding affects up to 60% of hormone replacement therapy (HRT) users. The mechanism of this bleeding is not understood. Reduced endometrial microvascular integrity appears to underlie breakthrough bleeding in pre-menopausal women and the aim of this study was to establish whether similar changes are seen in HRT users and hence to(More)
OBJECTIVE To establish the effect of hormone replacement therapy (HRT) on the expression of matrix metalloproteinase 9 (MMP-9) and the tissue inhibitor of MMPs, TIMP-1, in the endometrium of postmenopausal and perimenopausal women. DESIGN Prospective observational study. SETTING United Kingdom teaching hospital. PATIENT(S) Thirty-one perimenopausal(More)
BACKGROUND The Canadian guidelines recommend blood glucose (BG) screening starting at 2 h of age in asymptomatic 'at-risk' babies (including small-for-gestational-age [SGA] and large-for-gestational-age [LGA] infants), with intervention cut-offs of 1.8 mmol/L and 2.6 mmol/L. The present study reviews and audits this practice in full-term newborn(More)
In order to further explore the relationship between hemihyperplasia in children and the occurrence of embryonal tumours of childhood, the records at St Jude Children's Research Hospital were examined for patients who presented with a malignant tumour and hemihyperplasia. Of 27 evaluable patients, 19 had Wilm's tumour and one had massive bilateral(More)
Extracorporeal immunoadsorption and filtration was used in treatment of a 29-year-old woman with severe lupus nephritis. For the previous 35 days single-stranded DNA (ssDNA) antibody and immune-complex levels had been continuously raised with only partial improvement on prednisone therapy. Levels of immune complexes and ssDNA antibodies were substantially(More)
Paralytic agents are increasingly being used in animal studies of electrical ventricular defibrillation. Likewise, patients often have internal defibrillators implanted in conjunction with other heart surgery such as coronary artery bypass grafting (CABG). These patients usually will have been given a paralytic agent which is still present in the(More)
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