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Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue.
Ligand-based targeted delivery is an emerging platform in nanomedicine. We report herein on a peptide modified nanocarrier for a ligand-based targeted delivery system. The liposomal surface of theExpand
Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery.
TLDR
The systemic administration of a proapoptotic peptide with the delivery via PTNP significantly reduced the body weight of DIO mice, as evidenced by the targeted ablation of adipose endothelial cells. Expand
Sustained epidermal powder drug delivery via skin microchannels☆
TLDR
Sustained epidermal powder delivery efficiently and sustainably delivers powder drugs coated inside micro‐coating channels of a thick patch into the skin via tiny skin microchannels owing to slow water evaporation from skin MCs to gradually dissolve topical drug powder, while control delivery induces more instant drug release. Expand
Detection of atherosclerotic lesions and intimal macrophages using CD36-targeted nanovesicles.
TLDR
This molecular target approach may facilitate the in vivo noninvasive imaging of atherosclerotic lesions in terms of intimal macrophage accumulation and distribution and disclose lesion features related to inflammation and possibly vulnerability thereby facilitate early lesion detection and targeted delivery of therapeutic compounds to intimal Macrophages. Expand
Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.
TLDR
It is demonstrated that gold nanoparticles (AuNPs) inhibit proliferation and migration of both PCCs and PSCs by disrupting the bidirectional communication via alteration of the cell secretome through the ER-stress-regulated IRE1-dependent decay pathway (RIDD). Expand
Comparative assessments of crucial factors for a functional ligand-targeted nanocarrier
TLDR
Comparisons of PTNP prepared by the reverse-phase evaporation (REV) and lipid film hydration (HYD) methods with reference to physicochemical characteristics and in vivo and in vitro behavior revealed that the irreversible alteration in ligand conformation was caused by the organic solvent used to prepare the thin lipid film. Expand
Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues.
TLDR
The method described herein represents a protocol for the isolation and long-term maintenance of highly pure mouse MECs in high yields from adipose tissues. Expand
Therapeutic assessment of cytochrome C for the prevention of obesity through endothelial cell-targeted nanoparticulate system.
TLDR
Intravenous treatment of CytC-loaded PTNP resulted in a substantial reduction in obesity in high-fat diet fed wild-type (wt) mice, as evidenced by the dose-dependent prevention of the percentage of increase in body weight and decrease in serum leptin levels. Expand
Gold nanoparticle transforms activated cancer-associated fibroblasts to quiescence.
TLDR
It is demonstrated that GNP may be used as a tool to probe mechanisms of quiescence in CAFs and help device strategies to target stromal compartment exploiting the mechanisms of lipid utilization. Expand
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