Md Zahidul Karim

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PURPOSE To determine whether inducing calcification in the trabecular meshwork results in elevated IOP in living rats. To use this property to create an elevated IOP animal model by gene transfer of bone morphogenetic protein 2 (BMP2). METHODS Calcification was assessed by alizarin red staining in primary human trabecular meshwork (HTM) cells and alkaline(More)
PURPOSE We investigated whether T-588 can attenuate retinal ganglion cell (RGC) death induced by elevated intraocular pressure (IOP). METHODS IOP elevation was induced unilaterally by argon laser irradiation of the rat trabecular meshwork 4 days after an intracameral injection of India ink. We orally administered either the vehicle, or 10, 30, or 100(More)
PURPOSE Currently, nipradilol, an alpha-1 beta-blocker with a nitric oxide donative action, is used as an ocular hypotensive agent for glaucoma patients in Japan. The aim of the present study was to investigate the neuroprotective effect of nipradilol on optic nerve injury in rats. MATERIALS AND METHODS Using a calibrated cross-action forceps, a crush(More)
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