Md. Akil Hossain

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We have evaluated the effects of L-Dopa and carbidopa treatment (30 days) on dopamine (DA) turnover, intracellular cyclic AMP (cAMP) accumulation and tetrahydrobiopterin levels in the nigrostriatal pathway of rats with a unilateral 6-OHDA lesions (greater than 90% lesions). We observed significant increase in the 3,4-dihydroxy-phenylacetic acid/DA and(More)
We have evaluated (a) the effects of dopamine (DA) denervation on gamma-aminobutyric acid (GABA) turnover in terms of in vivo rate of GABA synthesis; (b) effects of DA D1 and D2 receptor agonists and antagonists on the in vivo GABA synthesis rate; and (c) the effects of GABAA and GABAB receptor agonists and antagonists on the intracellular accumulation of(More)
Mushrooms are a recognized component of the human diet, with versatile medicinal properties. Some mushrooms are popular worldwide for their nutritional and therapeutic properties. However, some species are dangerous because they cause toxicity. There are many reports explaining the medicinal and/or toxic effects of these fungal species. Cases of serious(More)
Salmonellosis is a common and widely distributed food borne disease where Salmonella typhimurium is one of the most important etiologic agents. The purpose of this study was to investigate the antimicrobial activity of Nymphaea tetragona alone and in combination with antibiotics against S. typhimurium. It also aimed to assess the plant for quorum sensing(More)
In the present study, we observed that tetrahydrobiopterin (BH4) levels were decreased significantly in the striatum, substantia nigra, frontal cortex, hypothalamus, and cerebellum of 25-month-old and in the cerebellum only in case of 18-month-old rats as compared to 4-month-old rats. In contrast, BH4 levels in adrenal glands of 25-month-old rats were(More)
The effects of a single and repeated electroconvulsive shock (ECS) (300 mA, 0.2 s) on tetrahydrobiopterin (BH4) levels and GTP-cyclohydrolase activity in the brain and adrenal glands of rats were examined. Twenty-four hours after the last ECS treatment (one/day for 7 days), biopterin levels were significantly elevated in the locus coeruleus, hippocampus,(More)
Repeated electroconvulsive shock (ECS) treatment (once per day for 7 days) produced a significant increase in tyrosine hydroxylase activity, GTP-cyclohydrolase activity and tetrahydrobiopterin (BH4) levels in the locus ceruleus and hippocampus from 1 to 4 days after the last treatment. These changes may be responsible for, or contribute to, the(More)
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