Mbaye Cissé

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The brain-derived neurotrophic factor (BDNF) has been involved in pre- and postnatal brain development. Moreover, abundant levels of this neurotrophin have been found in animal and human brain and serum. This study was aimed to assess the postnatal change profile of both serum and brain BDNF levels. By using immunoassay and reverse transcription-polymerase(More)
Body weight, condition score, deuteriated water dilution space, estimated body lipids and proteins, and calculated energy and protein balances were determined in 24 multiparous Holstein cows at wk 1, 7, 20, and 39 after parturition. Cows received two levels of energy concentrate (high and low groups) from wk 3. The objective was to estimate changes in body(More)
Cyclic AMP-dependent protein kinase (PKA) activity was involved in a number of brain functions such as cognitive process or aging. The measurement of PKA activity is traditionally based on the use of [(32)P]ATP in phosphorylation of specific protein. Recently non-isotopic PKA assays have been developed, but none has been tested on brain homogenates. This(More)
The cyclic AMP-dependent protein kinase (PKA) has been involved in the brain aging process and recent papers have reported age-associated changes in enzyme activity in rat brain. The present study was undertaken to assess simultaneously PKA activity and regulatory (R) subunit levels during maturation and aging. Five cohorts of rats of different ages were(More)
BACKGROUND Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD). METHODS The PKA activity and levels of (3)H-cAMP binding to PKA R regulatory subunits were measured in lymphoblasts from 10 BD and 10 control subjects. In(More)
Fifty-two Holstein dairy cows (27 primiparous) were used in a 2 x 2 factorial design during wk 9 to 39 of lactation to assess the effects of slow release recombinant bST (500 mg injected at 14-d intervals) and the effects of the level of energy concentrate in the diet on dairy performance. After a winter period, cows were turned out to pasture at wk 24 of(More)
Fifty Holstein dairy cows (26 primiparous) were used to evaluate effects of level of concentrate and of slow release recombinant bST on plasma hormones and metabolites. Blood was sampled at wk 14 and 20 of lactation, which was 5 and 11 wk after the first bST injection. In addition, at d 3 and 10 after the third bST injection, diurnal profiles of(More)
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