Mbang Adeyemi Owolabi

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The present study investigated the vasorelaxant action of the aqueous leaves extract of Persea americana on isolated rat aorta. The results showed that the extract produced significant vasorelaxation and that the effect is dependent on the synthesis or release of endothelium-derived relaxing factors (EDRFs) as well as the release of prostanoid. The extract(More)
Sickle cell anaemia (SCA) is associated with zinc deficiency; zinc supplementation may ameliorate some of its clinical manifestations including the relief of painful crisis. Subjects and Methods. Serum zinc levels were determined in 71 children with SCA and painful crisis and in equal numbers in steady state. Seventy-one children with AA genotype acted as(More)
In the present study, urinary excretion of the flavonoid metabolites of Persea americana was investigated. Aqueous extract of the leaves of P. americana was administered by gastric probe to Sprague–Dawley rats and urine samples were collected daily for five days. The urine samples were analyzed by reversed-phase HPLC–UV detection. The result obtained showed(More)
BACKGROUND In recent times, many herbal remedies are used to treat variety of ailments. The leaves of Vitex grandifolia is claimed to be effective in the treatment of diabetes mellitus and as a diuretic in the treatment of high blood pressure. However, there are no scientific reports on the therapeutic benefits or toxicity of this plant. This study(More)
BACKGROUND Heliotropium indicum Linn. (Boraginaceae) is used in Nigerian traditional medicine to treat tuberculosis with treatment lasting for 3 months; however, information on its toxicity is scarce. OBJECTIVE This study investigated the safety of the leaves of Heliotropium indicum after a 5 month oral administration. METHODS The leaves of H. indicum(More)
Hyperlipidemia, one of the major risk factors for cardiovascular diseases (CVDs) is associated with risks of ischemic stroke, atherosclerosis and myocardial infarction. It is characterized by abnormally high levels of triglycerides, cholesterol and reduced highdensity lipoproteins in the blood. In 2007, World Health 4 listed high level of cholesterol as one(More)
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