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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
It is shown that ablation of bulge cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kinase leads to complete loss of hair follicles but survival of the epidermis, indicating that bulge stem cells respond rapidly to epidermal wounding by generating short-lived 'transient amplifying' cells responsible for acute wound repair. Expand
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
It is shown that, after wounding, hair follicles form de novo in genetically normal adult mice, and these remarkable regenerative capabilities of the adult support the notion that wounding induces an embryonic phenotype in skin, and that this provides a window for manipulation of hair follicle neogenesis by Wnt proteins. Expand
Wnt activation in nail epithelium couples nail growth to digit regeneration
It is shown that nail stem cells (NSCs) reside in the proximal nail matrix and that the mechanisms governing NSC differentiation are coupled directly with their ability to orchestrate digit regeneration. Expand
Expansion of the Cell Plate in Plant Cytokinesis Requires a Kinesin-like Protein/MAPKKK Complex
It is concluded that expansion of the cell plate requires NACK1/2 to regulate the activity and localization of NPK1. Expand
Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
A role for Wnt signaling in the regulation of McSCs is defined and a mechanism for regeneration of complex organs through collaboration between heterotypic stem cell populations is illustrated. Expand
Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen.
- Mayumi Ito, K. Kizawa, K. Hamada, G. Cotsarelis
- Biology, Medicine
- Differentiation; research in biological diversity
- 1 December 2004
Findings support the notion that keratinocytes can "dedifferentiate" to a stem cell state in response to wounding, perhaps related to signals from the stem cell niche. Expand
Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling
It is demonstrated that after wounding or ultraviolet type B irradiation, melanocyte stem cells in the hair follicle exit the stem cell niche before their initial cell division, potentially depleting the pool of these cells. Expand
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
The fate analysis of HFSCs during aging revealed that organ aging is primed by the sustained DNA damage response against DNA damage that accumulates in renewing stem cells during aging. Expand
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.
A broader role is unexpectedly discovered for Wnt/β-catenin signaling in contributing to progenitor cell proliferation in nonhairy epithelia and interfollicular epidermis under homeostatic, but not inflammatory, conditions. Expand