Mayumi Imai

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AIM Low-density lipoprotein receptor knockout (LDLR-KO) mice fed a modified choline-deficient and amino acid-defined (mCDAA) diet show non-alcoholic steatohepatitis (NASH)-like pathophysiology. In order to pharmacologically benchmark this model, effects of pioglitazone (a thiazolidinedione) and candesartan cilexetil (an angiotensin II type 1 receptor(More)
The acute anti-ischemic and anti-anoxic effects of dextrorphan (DX) were compared with those of dizocilpine (MK-801) in a variety of animal models, and in vivo and in vitro testings under anoxic conditions. DX reduced the incidence of death in ischemic mice and improved the rotarod performance of mice with brain ischemia. The ischemically-impaired memory of(More)
The ef fec t of base changes a t the fourth pos i t ion from the 3 ' terminus of Esoheriohia c o l i i n i t i a t o r tRNA has been s tudied to t e s t the ' d i s criminator hypothesis ' which proposed tha t the nucleot ide in t h i s pos i t ion might have a r o l e i n the s p e c i f i c i t y of the aminoacylation r eac t ion . £ . ool i i n i t i a t(More)
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