Mayuko Kimura

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Two-component signal transduction is the primary signaling mechanism for global regulation of the cellular response to environmental changes. We used DNA microarray analysis to identify genes that were upregulated by acid stress in the cyanobacterium Synechocystis sp. PCC 6803. Several of these genes may be response regulators that are directly involved in(More)
We earlier showed that intestinal STC-1 cells can respond to five basic taste stimuli. Here, we investigated which receptors or channels are involved in the sensing of umami in STC-1 cells. T1R family and metabotropic glutamate receptors were not involved. In contrast, we found that N-Methyl-D-aspartate (NMDA) receptors are expressed in STC-1 cells by(More)
Transport assays using P-gp-expressing cell lines are commonly used to identify P-gp substrates and inhibitors in drug discovery. The P-gp cell-based assay is performed manually in 12- or 24-well plates and requires improvement for high-throughput screening. In this study, we established an efficient semiautomated 96-well transport assay using LLC-PK1 cells(More)
Short periods of breath-holding (BH) occur frequently during various kinds of sports activities. Increased minute oxygen uptake (V O 2), increased minute carbon dioxide output (V CO 2) and increased minute ventilation (VE) are some of the typical responses just after breaking the BH and resuming breathing and these parameters return to their steady levels(More)
Recent studies have shown the contribution of genetic determinants to athletes' physical ability. However, despite the fact that cognitive abilities like self-control and stress-tolerance influence athletes' competitive performance, few studies to date have investigated the association between genetic polymorphism, which is linked to cognitive ability and(More)
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