Mayreli Ortiz

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In this work we develop a discrete directorfield model for coarse-grained description of packing arrangements of DNA within bacteriophage virus heads. This computational lattice model allows us to explore the complex energy landscape of fully three-dimensional configurations of packaged DNA. By minimizing the system’s free energy by means of the simulated(More)
Celiac disease is an auto-immune disorder induced by ingestion of gluten in genetically predisposed individuals. Its diagnostics is more accurate using a combination of immunologic and genetic tests to detect of high levels of certain auto-antibodies and the presence human leukocyte antigen HLA-DQ2 or HLA-DQ8 genetic markers. In this work, we report the(More)
This is the first report on the formation of air-stable copper nitrosyl complexes. The interaction of nitric oxide, NO, with Cu(DTC)(2).3H(2)O (DTC: dithiocarbamate) and was studied in aqueous solution at pH 7.4 and 293 K. The stability constants were determined from UV-Vis data, using LETAGROP program. The high values obtained, log beta(1)=9.743(5) and log(More)
Two fluorescent ligands, 3,5-dimethyl-4-(6'-sulfonylammonium-1'-azonaphthyl)pyrazole (dmpzn, 1) and 3,5-dimethyl-4-(4'-N,N'-dimethylaminoazophenyl)pyrazole (dmpza, 2) were obtained by condensation of ketoenolic derivatives with hydrazine. 1 and 2 formed the novel dinuclear complexes [(H(2)O)(3)ClRu(micro-L)(2)RuCl(H(2)O)(3)] (3 or 4) and(More)
Numerous methods have been reported for the preparation of liposomes, many of which, in addition to requiring time-consuming preparative steps and the use of organic solvents, result in heterogeneous liposome populations of incontrollable size. Taking into consideration the phenomenon of spontaneous vesiculation and the theory of curvature, here we present(More)
Liposomes are colloidal structures formed by the self-assembly of lipid molecules in solution into spherical, self-closed structures through their amphiphilic properties. All liposome preparation protocols reported consist of several steps of preparation, homogenization, and purification, which are labor-intensive, arduous, and lengthy to execute. In this(More)
Carbon is a highly adaptable family of materials and is one of the most chemically stable materials known, providing a remarkable platform for the development of tunable molecular interfaces. Herein, we report a two-step process for the electrochemical hydrogenation of glassy carbon followed by either chemical or electrochemical chlorination to provide a(More)
There has been enormous interest in the last decade in development methods for the inorganic synthesis of metallic nanoparticles of desired sizes and shapes because of their unique properties and extensive applications in catalysis, electronics, plasmonics, and sensing. Here we report on an environmentally friendly, one-pot synthesis of metallic(More)
Liposomes are potential candidates as nanovesicles for the development of detection systems with improved sensitivity and detection limits, due to their capacity to encapsulate diverse types of signal enhancing molecules. An amperometric immunosensor exploiting enzyme encapsulating thermosensitive liposomes for the ultrasensitive detection of(More)