Mayra Pérez-Tapia

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To date, only the effect of a short-term antidepressant treatment (<12 weeks) on neuroendocrinoimmune alterations in patients with a major depressive disorder has been evaluated. Our objective was to determine the effect of a 52-week long treatment with selective serotonin-reuptake inhibitors on lymphocyte subsets. The participants were thirty-one patients(More)
Major depressive disorder (MDD) is a psychiatric illness that presents as a deficit of serotonergic neurotransmission in the central nervous system. MDD patients also experience alterations in cortisol and cytokines levels. Treatment with selective serotonin reuptake inhibitors (SSRIs) is the first-line antidepressant regimen for MDD. The aim of this study(More)
Major depressive disorder patients present chronic stress and decreased immunity. The Wistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis is overactivated. To determine whether chronic stress induces changes in corticosterone levels and splenic lymphoid tissue, 9-week-old male rats were subject to restraint stress (3 h(More)
Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. For instance, shorter sleep durations are associated with a rise in suffering from the common cold. The function of sleep in altering immune responses must be determined to understand how sleep(More)
Extensive research studies showed the existing interaction between different systems of the body that maintain the stability of homeostatic processes and which allow species to adapt to its environment in response to stressors. Adaptive responses to stressors activates adaptive-mechanisms, that result in the synthesis and release of several brain(More)
Breast cancer stem cells (BCSCs) overexpress components of the Nuclear factor-kappa B (NF-κB) signaling cascade and consequently display high NF-κB activity levels. Breast cancer cell lines with high proportion of CSCs exhibit high NF-κB-inducing kinase (NIK) expression. The role of NIK in the phenotype of cancer stem cell regulation is poorly understood.(More)
revealed that the treatment of IFN-g up to 24 hours suppressed the IL-4 1 TNFa-induced CCL11 expression, whereas the CCL11 expression was enhanced 3 days after the treatment. Conclusions: These results uncovered previously unsuspected contribution of IFN-g to the fibroblasts in allergic inflammatory milieu in terms of the change in production of certain(More)
32 years old female was referred because of fluctuating elevations of aminotransferases (AT) (4-to 19-fold normal) known last 6 months. She had positive HCV-RNA by RT-PCR an untypable genotype. Liver biopsy revealed chronic active hepatitis grade 2, stage 2. She also had Hashimotos thyroiditis with high titres of antithyroid antibodies. After 12 weeks of(More)
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Candida albicans causes opportunistic systemic infections with high mortality (30%-50%). Despite significant nephrotoxicity, amphotericin (AmB) is still used for the treatment of this serious fungal infection. Therefore, alternative treatments are urgently needed. Dialyzable leukocyte extracts have been used successfully to treat patients with mucocutaneous(More)
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