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Deletion of exon 10 of the human LH receptor impairs LH but not hCG action. Other splice variants of the LH receptor impair both LH and hCG action in other species. We hypothesized that alternatively spliced LH receptors are involved in luteolysis and luteal rescue with hCG in women. mRNA was extracted from human luteinized granulosa cells and from corpora… (More)
INTRODUCTION Heavy menstrual bleeding (HMB) diminishes individual quality-of-life and poses substantial societal burden. In HMB endometrium, inactivation of cortisol (by enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2)), may cause local endometrial glucocorticoid deficiency and hence increased angiogenesis and impaired vasoconstriction. We propose… (More)
BACKGROUND We describe an unplanned pregnancy in a 19-year-old with lipodystrophic diabetes caused by a mutation in the peroxisome proliferator-activated receptor gamma (PPARG) gene. The pregnancy was complicated by poor compliance with treatment, severe hypertriglyceridaemia and pancreatitis. CASE REPORT The patient presented at 6 weeks' gestation with… (More)
Context Repair of the endometrial surface at menstruation must be efficient to minimize blood loss and optimize reproductive function. The mechanism and regulation of endometrial repair remain undefined. Objective To determine the presence/regulation of CXCL4 in the human endometrium as a putative repair factor at menses. Patients/Setting Endometrial… (More)
Pregnant women in the UK are usually offered at least two ultrasound scans during their pregnancy. While these almost certainly cause no physical harm to the baby, communicating the findings to the parents, whether there is a problem or not, carries real potential for confusion, worry and perhaps unnecessary intervention.
OBJECTIVE To highlight the advantages of formal classification of causes of abnormal uterine bleeding from a clinical and scientific perspective. DESIGN Review and recommendations for local implementation. SETTING In the past, research in the field of menstrual disorders has not been funded adequately with respect to the impact of symptoms on… (More)