In decerebrate-decerebellate cats, dorsal column stimulation (DCst), rostral to bilateral dorsal column cuts, inhibited dorsal horn neurons discharging to various types of nociceptive stimuli. Similar inhibitory effects were observed from conditioning nucleus raphe magnus stimulation. Activation of this dorsal column-brainstem-spinal loop could be part of… (More)
In decerebrate-decerebellate cats, dorsal column stimulation (DCst) rostral to selective dorsal funicular cuts, to prevent antidromic activation of afferent DC fibers, produced primary afferent depolarization and modulated reflexes at the lower spinal level. These findings indicate the importance of a DC-brainstem-spinal loop in explaining the effects of DC… (More)
BACKGROUND Prevalence of metabolic syndrome (MS) in obese adolescents has been reported to range between 18-42%, depending on country of origin, thus suggesting an ethnic-based association between obesity and MS. AIM This study aims to investigate the magnitude of the association between obesity, insulin resistance and components of MS among adolescents… (More)
Rats with bilateral dorsal column (DC) lesions and chronic placement of stimulating electrodes on DC nuclei (DCN) and sham-operated rats were studied using the tail immersion test for phasic pain and the formalin test for tonic pain. DCN stimulation produced a clear inhibitory effect, through a supraspinal loop, in both phasic and tonic pain in awake rats.
In decerebrate-decerebellate cats, dorsal column stimulation (DCst) rostral to dorsal funicular cuts, to prevent antidromic activation of afferent dorsal column fibers, inhibited spinal flexion reflexes evoked by nociceptive stimuli. The effects of DCst above the cuts were compared to those below the cuts. Our findings indicate that the analgesic effects of… (More)