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Two novel CYP1 genes from teleost fish constituting a new subfamily have been cloned. These paralogous sequences are designated CYP1C1 and CYP1C2. Both genes were initially obtained from untreated scup Stenotomus chrysops tissues by RT-PCR and RACE. Scup CYP1C1 and CYP1C2 code for 524 and 525 amino acids, respectively, and share 80-81% identity at the(More)
Using genome-wide information to understand holistically how cells function is a major challenge of the postgenomic era. Recent efforts to understand molecular pathway operation from a global perspective have lacked experimental data on phenotypic context, so insights concerning biologically relevant network characteristics of key genes or proteins have(More)
We demonstrate that human-vision-model-based image quality metrics not only correlate strongly with subjective evaluations of image quality but also with human observer performance on visual recognition tasks. By varying amorphous silicon image system design parameters, the performance of human observers in target identification using the resulting test(More)
This paper explores the problem of incorporating linguistic constraints into document image decoding, a communication theory approach to document recognition. Probabilistic character n-grams (n=2–5) are used in a two-pass strategy where the decoder first uses a very weak language model to generate a lattice of candidate output strings. These are then(More)
Signal processing is an integral part of cell biology. The associated algorithms are implemented by signaling pathways that cell biologists are just beginning to understand and characterize. Our objective in the context of signal processing is to understand these algorithms and perhaps emulate them in other contexts such as communication and speech(More)
Bacterial chemotaxis refers to the locomotory response of bacteria to chemical stimuli, where the general biological function is to increase exposure to some substances while reducing exposure to others. In this paper, we introduce an algorithm for surface mapping based on a model of the biological signaling network responsible for bacterial chemotaxis. The(More)
The mitogen-activated protein kinase (MAPK) cascade is an essential component of a wide variety of eukaryotic cell signaling pathways including ones involved in growth, differentiation, and apoptosis. This highly conserved series of three enzymes has been extensively studied, and a wide range of steady state as well as dynamic data has been published(More)