Maya J Pandya

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Ebolaviruses are highly lethal filoviruses that cause hemorrhagic fever in humans and nonhuman primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent global health need. Here, we describe the design, biophysical characterization, and(More)
Tetrahydrobiopterin is an essential cofactor for aromatic amino acid hydroxylases, ether lipid oxidase and nitric oxide synthases. Its biosynthesis in mammals is regulated by the activity of the homodecameric enzyme GCH (GTP cyclohydrolase I; EC 3.5.4.16). In previous work, catalytically inactive human GCH splice variants differing from the wild-type enzyme(More)
Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of once-daily formulations. A controlled-release system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microspheres by the emulsion solvent diffusion(More)
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs). In a combined biochemical and immunological approach, we characterize the biochemical interaction of tumor-associated peptides with human Hsp70 and show that the strength of this(More)
At the surface of Aβ(1-40) amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for(More)
Economic development of a country depends on a well formulated and effective strategic planning. Most of the data used for resources planning and management are spatial in nature. Geographic Information System (GIS) today is one of the major decision making tools in the areas of resources planning and management. One of the spin-offs of space research is(More)
  • Abboud, H Floden, D Thompson, G Genc, S Oravivattanakul, F Alsallom +111 others
  • 2016
Impact of mild cognitive impairment on outcome following deep brain stimulation surgery for Parkinson's disease. Single-injection thoracic paravertebral block and postoperative analgesia after mastectomy: a retrospective cohort study. Reply: Conventional risk factors and cardiovascular outcomes of patients with inflammatory bowel disease with confirmed(More)
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