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Critical role of P1-Runx1 in mouse basophil development.
Runx1(P1N/P1N) mice are deficient in the transcription factor distal promoter-derived Runt-related transcription factor 1 (P1-Runx1) and have a > 90% reduction in the numbers of basophils in the BM,Expand
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Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
It has been reported that the intracellular antiapoptotic factor myeloid cell leukemia sequence 1 (Mcl-1) is required for mast cell survival in vitro, and that genetic manipulation of Mcl-1 can beExpand
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Molecular framework for response to imatinib mesylate in systemic sclerosis.
Systemic sclerosis (SSc) is an autoimmune disease in which the tyrosine kinases platelet-derived growth factor receptor (PDGFR) and Abl are hypothesized to contribute to the fibrosis and vasculopathyExpand
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A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis
Deposits of Ig and complement are abundant in affected joints of patients with rheumatoid arthritis (RA) and in animal models of RA in which antibodies are demonstrably pathogenic. To identifyExpand
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Autoimmunity against Fibrinogen Mediates Inflammatory Arthritis in Mice
Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the presence of anticitrullinated protein Abs, although the exact targets and role of anticitrullinated protein autoimmunity inExpand
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Treatment with Cl-amidine, a peptidyl arginine deiminase (PAD) inhibitor, significantly reduces collagen-induced arthritis (CIA) (50.6)
Antibodies to citrullinated protein antigens (ACPA) are specific for rheumatoid arthritis (RA). Post-translational citrullination of epitopes to which ACPA are directed is catalyzed by PADs. We haveExpand
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