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  • Michio Shimabukuro, May-yun Wang, Yuezhang Zhou, Christopher B. Newgard, Roger H. Unger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 4 August 1998)
  • Obesity causes its complications through functional and morphologic damage to remotely situated tissues via undetermined mechanisms. In one rodent model of obesity, the Zucker diabetic fatty fa/faExpand
  • Michio Shimabukuro, Moritake Higa, Yuezhang Zhou, May-yun Wang, Christopher B. Newgard, Roger H. Unger
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1998 (First Publication: 4 December 1998)
  • We reported that the lipoapoptosis of beta-cells observed in fat-laden islets of obese fa/fa Zucker Diabetic Fatty (ZDF) rats results from overproduction of ceramide, an initiator of the apoptoticExpand