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BACKGROUND Hyperglycemia is acknowledged as an independent risk factor for developing diabetes-associated atherosclerosis. At present, most therapeutic approaches are targeted at a tight glycemic control in diabetic patients, although this fails to prevent macrovascular complications of the disease. Indeed, it remains highly controversial whether or not the(More)
The incidence of cardiovascular diseases in premenopausal women is lower than in men or postmenopausal women. This study reports the discovery of a low grade of systemic inflammation, including monocyte adhesion to arterial endothelium, elicited by menopause or estrogen depletion. Chronic treatment with low dose of 17-beta-estradiol or inhibition of the(More)
Angiotensin II (Ang-II) displays inflammatory activity and is implicated in several cardiovascular disorders. This study evaluates the effect of cis- and trans (t)-resveratrol (RESV) in two in vivo models of vascular inflammation and identifies the cardioprotective mechanisms that underlie them. In vivo, Ang-II-induced arteriolar leukocyte adhesion was(More)
Fenugreek (trigonella foenum graecum) is one of the most widely used medicinal plants in folk medicine. It is known to have a diuretic, cardio tonic, hypotensive, hypoglycemic and hypolipidemic effect. This study was designed to evaluate the hypoglycemic effect of Trigonelline isolated from Iraqi fenugreek seeds in normal and alloxan –diabetic rabbits.(More)
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