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  • M J Wells
  • 1980
The circulatory system of cephalopods is based on a trio of hearts, with two pairs of associated ganglia linked to the CNS by a pair of visceral nerves. The beat of the hearts was recorded from free-moving octopuses before and after surgical removal or disconnexion of elements of the nervous system. Severing the visceral nerves does not stop the hearts,(More)
During experiments to identify putative hepatic receptors for thrombin-antithrombin (TAT) complexes, a 45-kDa protein was identified by ligand blotting. Following gel purification, amino acid sequencing revealed the 45-kDa TAT-binding polypeptide to be cytokeratin 18 (CK18). The presence of CK18 on the surface of intact rat hepatoma cells was demonstrated(More)
A series of 4- aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazole ( metrazole ) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N- amylbenzamide (6) was(More)
Thirty participants explored two virtual mazes. Half of the participants used a hand-controller (joystick); the other half used the Virtual Motion Controller (VMC), a body-controller interface. Maneuvering performance, as measured by the precision with which subjects followed a marked route, was slightly better with the joystick. Route learning, as measured(More)
The concentrations of 13-cis-retinoic acid and N-(2-hydroxyethyl)retinamide in serum and tissues from mice were measured after oral dosing with 10 mg/kg. Serum levels of the drugs reached their maxima within 15-30 min and then declined in an exponential fashion with t1/2 values of 19 min and 2.9 hr, respectively. Tissue levels of 13-cis-retinoic acid(More)
SUMMARY Octopus vulgaris can regulate its oxygen uptake in a closed respirometer down to a P02 of less than 70 mmHg. As the tankwater P02 falls the hearts slow down. Pulse amplitudes and mean pressures fall in the afferent bran-chial vessels and in the dorsal aorta. Despite behavioural changes — expansion of the interbrachial web and extension of the arms —(More)
The prevalence of antithrombin (AT) deficiency in the general population has been variously estimated to be between 0.05 and 5 per 1,000 in the population; 2,491 blood donors were screened in an attempt to clarify this issue using plasma samples taken from the blood donor units. From this initial population, 122 individuals were identified as having plasma(More)
OBJECTIVES To determine whether functional antithrombin III (AT-III) levels measured by a factor Xa inhibition (AT-III-Xa) assay identifies AT-III deficient individuals more reliably than functional AT-III levels measured by a thrombin inhibition (AT-III-IIa) assay. STUDY DESIGN Cross-sectional study. PATIENT POPULATION Sixty-seven members of a large(More)