Maximilian Sergio

Learn More
The design and characterization of an imaging sensor based on single photon avalanche diodes is presented. The sensor was fully integrated in a 0.35μm CMOS technology. The core of the imager is an array of 4x112 pixels that independently and simultaneously detect the arrival time of photons with picosecond accuracy. A novel event-driven readout scheme(More)
We report the first fully integrated single photon avalanche diode array fabricated in 0.35 mum CMOS technology. At 25 mum, the pixel pitch achieved by this design is the smallest ever reported. Thanks to the level of miniaturization enabled by this design, we were able to build the largest single photon streak camera ever built in any technology, thus(More)
Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for(More)
This paper presents a CMOS array of 64 48 pixels capable of detecting single photons with timing accuracies better than 80ps. Upon photon arrival, a digital pulse is generated and routed by an event-driven digital readout scheme to a specific location for further processing. This method allows non-sequential row-wise and simultaneous column-wise detection(More)
Background. As interest on wearable computing [1] increases, researchers are looking for new materials to use as a support for electronics. A fabric substrate is very appealing: it is elastic and extensible [2], supported by a well known technology and produced at low-cost. State of the art. Some smart pressure-sensors interfacing with a flexible substrate(More)
Precision medicine in oncology requires an accurate characterization of a tumor molecular profile for patient stratification. Though targeted deep sequencing is an effective tool to detect the presence of somatic sequence variants, a significant number of patient specimens do not meet the requirements needed for routine clinical application. Analysis is(More)
INTRODUCTION The sense of touch plays an important role in everyday life. It provides the body with early contact to surrounding objects. By touching an object, we can tell if it is sharp or smooth; by holding it, we can estimate its weight. Skin is the most extended sensor of the entire human body. The haptic interface gives the first feedback to object(More)
We present in this chapter some key technologies for lab-on-a-chip (LOC) applications, in particular related to magnetic transport and optical detection. Our objective is to show how these technologies can be realized and operate synergistically to support integrated biodetection. Magnetic microparticles (“beads”) have proven to be versatile and reliable(More)
  • 1