Maximilian Hoffmann

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High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge in neuroscience. Here we demonstrate simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain. Our technique captures the dynamics of spiking neurons in volumes of ∼700(More)
Capturing the dynamics of neuronal activity across whole nervous systems at high temporal resolution has been a long-standing dream in neuroscience. While point-scanning microscopy methods provide the necessary 3D resolution, their volume acquisition rates are limited. Wide-field microscopes on the other hand do not provide sufficient optical sectioning(More)
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