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CONTEXT Oral contraceptive (OC) pills are effective, but poor compliance increases rates of pregnancy during treatment. OBJECTIVE To compare the contraceptive efficacy, cycle control, compliance, and safety of a transdermal contraceptive patch and an OC. DESIGN Randomized, open-label, parallel-group trial conducted October 1997 to June 1999. SETTING(More)
A review was made of 88 adult institutionalized patients with spastic cerebral palsy and contractural deformity of the hips. 21 were untreated for dislocated hip, and 11 of these suffered from hip pain. The degree of pain was directly related to neurological maturity and to the coexistence of athetosis and spasticity. Decubitus ulcers and perineal care(More)
We have reviewed the results of operations to stabilise the paralytic hip and to correct and stabilise the deformed spine of children with myelomeningocele. Despite a high complication rate the spinal operations were frequently successful. The hip operations were less satisfactory, with stabilisation of the hip eventually achieved in 69 per cent of the(More)
We wished to determine the specificity of smooth-pursuit eye tracking dysfunction to schizophrenia and the prevalences of dysfunction among functionally psychotic and normal individuals. Therefore, we investigated pursuit tracking in a large sample of psychotic patients, normal subjects, and first-degree relatives (N = 482). Patients were recruited as part(More)
To determine whether abnormalities in brain morphology are present at the onset of illness, patients with schizophrenia, schizophreniform and bipolar disorders, and major depression who were experiencing their first episodes of psychosis were compared with normal and medical control subjects. The schizophrenic patients had larger third ventricles but not(More)
Forty-four hips in 22 children between the ages of 2.0 and 6.0 years (mean, 4.0 years) with cerebral palsy were followed-up prospectively for a minimum of 5 years. Of the 44 hips studied preoperatively, 20 were radiologically normal, 24 were subluxed, and one was dislocated. Five years postoperatively, 39 hips were normal, five were subluxed, and none was(More)
OBJECTIVE To evaluate the topical effect of various agents, currently used in the treatment of melting ulcers, on gelatinase activity present in the tear film of normal dogs. ANIMAL STUDIED Eight normal adult beagles. PROCEDURES Each animal received the following agents: cyclosporine A 1%, N-acetylcysteine 10%, ciprofloxacin 0.3%,(More)
The literature indicates that whether or not schizophrenic patients are reported to have significant lateral ventricular enlargement depends on control, and not schizophrenic-group values. This discrepancy does not result from differences in age, the ratio of males to females, the number of control subjects used in each study, or whether control groups are(More)
Neuropathic fractures are common after major surgical procedures to stabilize the hip or spine in patients with myelomeningocele. Complications resulting from such fractures are frequently observed. The fractures occur particularly in the more severely involved children and are associated with prolonged immobilization after surgery. The authors advise that(More)