Max Rieger

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Several highly relevant applications for gas sensor systems cannot be adequately addressed today due to the limited sensitivity and selectivity of available low-cost sensors. We present a novel approach to simultaneously boost sensitivity and selectivity by using low-cost, selective micro pre-concentrators (μPC) to accumulate target molecules.(More)
An integrated gas measurement system is presented which combines MEMS gas sensors with a micro gas pre-concentration device. Designed to increase gas sensor selectivity and sensitivity, the pre-concentrator samples gases and releases them by thermal desorption. Simulations show that the design works very well for volatile organic compounds in the ppb(More)
The inhibition potencies of covalent inhibitors mainly result from the formation of a covalent bond to the enzyme during the inhibition mechanism. This class of inhibitors has essentially been ignored in previous target-directed drug discovery projects because of concerns about possible side effects. However, their advantages, such as higher binding(More)
In the present study we use quantum-chemical calculations to investigate how the reactivity of vinyl sulfone-based compounds can be modified from an irreversible to a reversible reaction with thiols. Based on the predictions from theory, an array of nine different vinyl sulfones with systematically varying substitution pattern was synthesized and their(More)
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