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We present a set of Porites coral oxygen isotope records from the tropical and subtropical Western Indian Ocean covering the past 120-336 years. All records were thoroughly validated for proxy response to regional climate factors and their relation to large-scale climate modes. The records show markedly different imprints of regional climate factors. At the(More)
1. Lowering of the extracellular Mg(2+)-concentration induces various patterns of epileptiform activity in combined rat entorhinal cortex-hippocampal brain slices. After a prolonged period of exposure to Mg(2+)-free medium seizure-like events in the entorhinal cortex change to a state of late recurrent discharges which cannot be blocked by clinically(More)
Epileptic syndromes frequently start at childhood and therefore it is crucial to test new anticonvulsants at immature stages of the nervous system. We compared the effects of the gamma-aminobutyric acid (GABA) uptake inhibitor tiagabine [(R)-N-(4, 4-bis(3-methyl-2-thienyl)but)3-en-1-yl nipecotic acid] on low-Mg(2+)-induced epileptic discharges in brain(More)
Cars offer an increasing number of infotainment systems as well as comfort functions that can be controlled by the driver. In our research, we investigate new interaction techniques that aim to make it easier to interact with these systems while driving. We suggest utilizing the steering wheel as an additional interaction surface. In this paper, we present(More)
Free-hand interaction with large displays is getting more common, for example in public settings and exertion games. Adding haptic feedback offers the potential for more realistic and immersive experiences. While vibrotactile feedback is well known, electrical muscle stimulation (EMS) has not yet been explored in free-hand interaction with large displays.(More)
Pedestrian navigation systems require users to perceive, interpret, and react to navigation information. This can tax cognition as navigation information competes with information from the real world. We propose actuated navigation, a new kind of pedestrian navigation in which the user does not need to attend to the navigation task at all. An actuation(More)
As displays in public space are augmented with sensors, such as the Kinect, they enable passersby to interact with the content on the screen. As of today, feedback on the user action in such environments is usually limited to the visual channel. However, we believe that more immediate and intense forms, in particular haptic feedback, do not only increase(More)
Cars offer an increasing number of infotainment systems as well as comfort functions that can be controlled by the driver. With our research we investigate new interaction techniques that aim to make it easier to interact with these systems while driving. In contrast to the standard approach of combining all functions into hierarchical menus controlled by a(More)
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A new hardware cell model for electrophysiological recording has been constructed which allows for the assessment of voltage clamp accuracy in different recording situations. Each compartment consists of a capacitor in parallel with a variable resistor and can be connected to other compartments by a variable axial resistance. The simulated membrane(More)