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A new approach for automated peak picking of multidimensional protein NMR spectra with strong overlap is introduced, which makes use of the program AUTOPSY (automated peak picking for NMR spectroscopy). The main elements of this program are a novel function for local noise level calculation, the use of symmetry considerations, and the use of lineshapes(More)
Assembly modelling is an important task within the design process for mechanical engineering. Constraint-based modelling is an adequate approach to this task. Kinematic mechanisms often have multiple interacting loops which are diicult to solve by a geometric constraint solver. In this paper, we introduce kinematic chain substitution, which is an elegant(More)
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