Mauro Waldemar Keiserman

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OBJECTIVES This double-blind trial evaluated the efficacy and safety of abatacept or infliximab vs placebo. The primary objective of this study was to evaluate the mean change from baseline in Disease Activity Score (based on erythrocyte sedimentation rates; DAS28 (ESR)) for the abatacept vs placebo groups at day 197. METHODS Patients with rheumatoid(More)
OBJECTIVE To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). METHODS This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We(More)
OBJECTIVE To compare the efficacy and safety of subcutaneous (SC) and intravenous (IV) abatacept. METHODS In this phase IIIb double-blind, double-dummy, 6-month study, patients with rheumatoid arthritis (RA) and inadequate responses to methotrexate were randomized to receive 125 mg SC abatacept on days 1 and 8 and weekly thereafter (plus an IV loading(More)
OBJECTIVE To assess the efficacy and safety of abatacept in biological-naive patients with rheumatoid arthritis and an inadequate response to methotrexate treated in the long-term extension (LTE) of the ATTEST trial. METHODS Patients randomly assigned to abatacept, placebo or infliximab completing the 1-year double-blind period were eligible to receive(More)
Denver Arthritis Clinic, Denver, CO, USA; Pontificial Catholic University, School of Medicine, Porto Alegre, Brazil; Health Research of Oklahoma, Oklahoma City, OK, USA; Arthritis & Osteoporosis Center, Flowood, MS, USA; Centro Medico Privado De Reumatologia, Tucuman, Argentina; St Augustine's Hospital, Durban, South Africa; Centro de Investigacion del(More)
OBJECTIVE To analyze the clinical effect of enthesitis in a large Brazilian cohort of patients with spondyloarthritis (SpA). METHODS A common protocol of investigation was prospectively applied to 1505 patients with SpA in 29 centers in Brazil. Clinical and demographic variables and disease indexes were investigated. The Maastricht Ankylosing Spondylitis(More)
OBJECTIVE Spondyloarthritides (SpA) can present different disease spectra according to ethnic background. The Brazilian Registry of Spondyloarthritis (RBE) is a nationwide registry that comprises a large databank on clinical, functional, and treatment data on Brazilian patients with SpA. The aim of our study was to analyze the influence of ethnic background(More)
OBJECTIVE Assess longterm tolerability, safety, and efficacy of subcutaneous (SC) abatacept (ABA) in methotrexate-refractory patients with rheumatoid arthritis (RA). METHODS The phase III, multinational Abatacept Comparison of Sub[QU]cutaneous Versus Intravenous in Inadequate Responders to MethotrexatE (ACQUIRE) trial comprised a 6-month, randomized,(More)
DISCUSSION This is the first report of the use of oral linezolid for the successful treatment of staphylococcal liver abscess in CGD. Linezolid is an oxazolidinone antibiotic that has a bacteriostatic action by inhibition of the 70s ribosomal initiation complex. Linezolid is rapidly and completely absorbed after oral administration. It is used in complex or(More)