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c-Myc functions through direct activation or repression of transcription. Using cDNA microarray analysis, we have identified c-Myc-responsive genes by comparing gene expression profiles between c-myc null and c-myc wild-type rat fibroblast cells and between c-myc null and c-myc null cells reconstituted with c-myc. From a panel of 4400 cDNA elements, we(More)
c-Myc functions through direct activation or repression of transcription. Using cDNA microarray analysis, we have identified c-Myc-responsive genes by comparing gene expression profiles between c-myc null and c-myc wildtype rat fibroblast cells and between c-myc null and c-myc null cells reconstituted with c-myc. From a panel of 4400 cDNA elements, we found(More)
The proto-oncogene c-myc encodes a highly conserved nuclear phosphoprotein that functions as a transcription factor in the cell. The discovery of deregulated c-myc in a variety of tumours and the ability of c-myc to transform cells either alone or in cooperation with the ras oncogene indicate that the activation of cmyc is involved in tumorigenesis. In(More)