Maurizio Spandre

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OBJECTIVES Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS 2622 patients were included.(More)
BACKGROUND AND STUDY AIMS Endoscopic exploration of the small bowel is potentially of prime importance in studying gastrointestinal bleeding of obscure origin, diarrhea and malabsorption, neoplasia, and other clinical conditions, but the method is still problematic because of the limited efficacy of sonde-type enteroscopes. This study evaluates the(More)
PURPOSE The aim of this study was to determine the spatial distribution and histotype of small colorectal polyps and to determine the validity of distal-small colorectal polyps as markers of proximal neoplasms. METHODS In 366 patients who underwent total colonoscopy and removal of all polyps, the presence and features of polyps were recorded. The(More)
OBJECTIVE To assess the efficacy of a hereditary non-polyposis colon cancer (HNPCC) identification and surveillance policy. METHODS Familial clustering of colorectal cancer (CRC) and extracolonic cancers (ECs) was investigated in 1520 consecutive CRC patients and relatives. HNPCC was identified by Amsterdam criteria, and individuals at risk were offered(More)
BACKGROUND Paracentesis-induced circulatory dysfunction is a well-known complication of large volume paracentesis. Albumin infusion (8g of albumin/L of ascites removed) is effective in preventing it, but high costs and scant availability limit its use. AIM To compare standard vs half albumin doses. METHODS Seventy cirrhotic patients treated with large(More)
Of 1696 endoscopically removed polyps in the authors' series 62% were adenomas and 31 showed invasive carcinoma. 8 patients were not available for follow-up, and 7 underwent surgical resection with negative findings. There was no evidence of recurrent cancer in the remaining 16 over a 1-6 year span of follow-up, although one unrelated rectal carcinoma and(More)
Collagenous colitis is a newly identified condition, with clinical features of chronic watery diarrhea and abdominal pain. Histologically the main characteristic is the presence of a thick collagen band below the surface epithelium. Collagenous colitis occurs in adults, especially women. Endoscopy reveals no particular changes in the intestinal mucosa.(More)
A number of blood clotting parameters have been determined in the plasma of 25 women who had not previously taken steroid contraceptives. After the administration of an oestroprogestinic association (ethynyloestradiol 0.05 mg + norgestrol 0.25 mg) for five cycles, the same subjects were controlled again for the determination of the same haematochemical(More)
Forty patients with irritable bowel syndrome were randomly allocated to treatment with octylonium bromide (20 mg TID) or cimetropium bromide (50 mg BID) in a double-blind trial lasting for six weeks. Drugs were taken before meals, according to a double-blind schedule. Clinical evaluations were made of digestive and other symptoms, objective findings (pain(More)
The headword “overlap syndromes” of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct entities or they are only variants of(More)