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Chemotherapy for brain tumours has been limited because of difficulty in achieving adequate exposure to the tumour without systemic toxicity. We have developed a method for local sustained release of chemotherapeutic agents by their incorporation into biodegradable polymers. Implantation of the drug-impregnated polymer at the tumour site allows prolonged(More)
The results of a multi-institutional phase I trial evaluating the safety of surgically implanted biodegradable 1,3-bis(chloro-ethyl)-1-nitrosourea (BCNU) impregnated polymer as the initial therapy for malignant brain tumors are reported. This is the first study of locally delivered BCNU and standard external beam radiation therapy (XRT) given concurrently.(More)
Eighth nerve sections have been performed to control debilitating tinnitus, with various success rates (45% to 76%). Patients with a unilateral profound sensorineural hearing loss and disabling tinnitus perceived in that ear are candidates for such surgery. The concept of a selective cochlear neurectomy with preservation of the vestibular nerve is(More)
In the early stages of running of the CRESST dark matter search using sapphire detectors at very low temperature, an unexpectedly high rate of signal pulses appeared. Their origin was finally traced to fracture events in the sapphire due to the very tight clamping of the detectors. During extensive runs the energy and time of each event was recorded,(More)
We have developed a detector, consisting of a cryogenic calorimeter with a scintillating crystal as absorber, and a second calorimeter for the detection of the scintil-lation light, both operated at 12 mK. Using a CaWO 4 crystal with a mass of 6 g as scintillating absorber, we have achieved a discrimination of nuclear recoils against electron recoils with a(More)
CUORE is a proposed tightly packed array of 1000 T eO2 bolometers, each being a cube 5 cm on a side with a mass of 750 gms. The array consists of 25 vertical towers, arranged in a square, of 5 towers by 5 towers, each containing 10 layers of 4 crystals. The design of the detector is optimized for ultralow-background searches for neutrinoless double beta(More)
Metschnikowiaceae may show natural, strain-dependent antifungal properties, so they are employed in agriculture as natural, safe alternatives to pesticides. With this paper, we documented the ability of the recently described Metschnikowia IHEM 25107 to inhibit growth of several molds, including diverse Aspergillus species and dermatophytes. This biocontrol(More)
CUORICINO is a bolometric experiment on Neutrinoless Double Beta Decay (DBD0ν) of 130 Te. It consists of an array of 62 TeO2 crystals with a total mass of ∼ 40.7 kg. While being a self consistent experiment CUORICINO is also a good test for the feasibility of the next generation experiment CUORE, ∼750 kg of TeO2 bolometric mass. In this paper last results(More)