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Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate
- N. Hamon, Maurizio Quintiliani, J. Balzarini, C. Mcguigan
- Chemistry, MedicineBioorganic & Medicinal Chemistry Letters
- 13 March 2013
It is discovered that introduction of fluorine atoms on the 2 position of 2-deoxyribose enables the phosphorylation step: in fact, the stability of the prodrugs increases with the degree of 2,2-difluoro-2-de oxygenribose-1-phosphate.
Gold nanoparticles stabilized with aromatic thiols: Interaction at the molecule-metal interface and ligand arrangement in the molecular shell investigated by SR-XPS and NEXAFS
Small gold nanoparticles capped with 4-trimethylsilylethynyl-1-acetylthiobenzene (SEB) were prepared with spherical shape and different mean sizes (5–8 nm). The functionalized gold nanoparticles…
Synthesis and photoinduced electron-transfer properties of phthalocyanine-fullerene conjugates.
Complementary time-dependent density functional calculations supported the spectral assignment, namely, the spectral identity of the ZnPc(*+) radical cation and the C60 (*-) radical anion as seen in the differential absorption spectra.
Synthesis and nonlinear optical properties of tetrahedral octupolar phthalocyanine-based systems.
- Maurizio Quintiliani, J. Pérez-Moreno, I. Asselberghs, P. Vázquez, K. Clays, T. Torres
- Chemistry, MedicineThe journal of physical chemistry. B
- 19 April 2010
It is presented for the first time that the octupolar symmetry by itself, realized by four nondipolar moieties in a tetrahedral arrangement, results also in a large second-order nonlinear response.
Network assembly of gold nanoparticles linked through fluorenyl dithiol bridges
Gold nanoparticles stabilized by two novel bifunctional fluorenyl thiols, generated in situ from 9,9-didodecyl-2,7-bis(acetylthio)fluorene (1) and…
Functionalisation of Phthalocyanines and Subphthalocyanines by Transition-Metal-Catalysed Reactions
The functionalisation of phthalocyanines and subphthalocyanines by transition-metal-catalysed reactions is reviewed. 1 Introduction 2 Transition-metal-mediated cross-coupling reactions 2.1…
Design, synthesis, and biological evaluation of C1-phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate
A novel series of phenoxy C1–phosphonamidate derivatives of 2-deoxy-d-ribose have been synthesised as stable analogues of 2-deoxy-α-d-ribose-1-phosphate. A number of synthetic routes were explored…
Synthesis of diiodo butadiynyl-bridged bisphthalocyaninatozinc(II) complexes.
- Maurizio Quintiliani, E. M. García-Frutos, P. Vázquez, T. Torres
- Chemistry, MedicineJournal of inorganic biochemistry
- 1 March 2008
The reactivity of the two iodo substituents was explored to prepare a novel bisphthalocyanine containing two ethynylphenyl moieties, thus pointing out the possibility of incorporating other electro and/or photoactive moieties in the BisPc system, taking advantage of the iodo-functionalization.
Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides
- Maurizio Quintiliani, L. Persoons, +5 authors C. Mcguigan
- Medicine, ChemistryBioorganic & Medicinal Chemistry
- 26 May 2011
Interestingly, 2′-deoxy-2′,2′-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase.
Synthesis, Characterisation and Nonlinear Optical Properties of Two‐Dimensional Octupolar Systems Based on Phthalocyanine Compounds
Four phthalocyanine-based compounds with pseudo D3h symmetry have been synthesised and fully characterised. Palladium cross-coupling methodologies were employed in order to synthesise…