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Synthesis and assignment of absolute configuration of the iridoid 9-deoxygelsemide.
The first enantioselective synthesis of 9-deoxygelsemide, belonging to a rare group of iridoids isolated from Gelsemium plants, is described. The key synthetic steps are a variant of theExpand
Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.
TLDR
This paper reports the discovery, synthesis, and structure-activity relationships of substituted 2-aminopyrimidines, representing a new class of reversible VCP inhibitors, identified in a HTS campaign against recombinant VCP. Expand
Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes.
TLDR
The synthesis of racemic 17-A 4-NeuroP and 14-A4-Ne neuroP validated a general approach to several regioisomeric cyclopentenone A4- and J4- NeuroPs needed for biological tests. Expand
Beckmann Rearrangement of Oximes Catalyzed by Cyanuric Chloride in Ionic Liquids
The Beckmann rearrangement of a variety of ketoximes has been carried out in imidazolium-based ionic liquids in the presence of catalytic amounts of 2,4,6-trichloro[1,3,5]triazine. This mild andExpand